I3C supports hormonal balance as it prevents cellular damage therefore benefiting the body's immune system. Dietary indole compounds as found in broccoli, cabbage, and other cruciferous vegetables exert a strong protective effect on tissues such as breast, cervix, and prostate that are most susceptible to the effects of undesirable estrogen metabolites, such as 16-alpha-hydroxyestrone. Indole compounds favorably influence steroid hormone metabolism and help rebalance estrogen in favor of 2-hydroxyestrone, a protective estrogen metabolite. Dietary indoles also stimulate liver detoxification enzymes, inhibit DNA damage, and regulate cell cycle progression. Indole-3-carbinol (I3C), the most prominent dietary indole, readily breaks down in the presence of stomach acid into diindolylmethane (DIM) and other associated indole compounds that are subsequently absorbed.